Pharmaceutical applications of solid dispersion systems: dissolution of griseofulvin-succinic acid eutectic mixture.

The dissolution profile of the griseofulvin-succinic acid eutectic mixture system was evaluated using the powder and constant-surface are tablet methods. Factors contributing to the enhancement of griseofulvin dissolution from the dispersion in succinic acid are discussed. Contrary to the original proposal of Sekiguchi and coworkers, dissolution rates of driseofulvin from solid dispersions were found to be markedly affected by the particle size of solid dispersions.