Chiou W L, Niazi S
J Pharm Sci. 1976 Aug;65(8):1212-4. doi: 10.1002/jps.2600650820.
The dissolution profile of the griseofulvin-succinic acid eutectic mixture system was evaluated using the powder and constant-surface are tablet methods. Factors contributing to the enhancement of griseofulvin dissolution from the dispersion in succinic acid are discussed. Contrary to the original proposal of Sekiguchi and coworkers, dissolution rates of driseofulvin from solid dispersions were found to be markedly affected by the particle size of solid dispersions.
采用粉末法和恒定表面积片法对灰黄霉素-琥珀酸共熔混合物体系的溶出曲线进行了评估。讨论了有助于提高灰黄霉素从其在琥珀酸中的分散体中溶出的因素。与关口及其同事最初的提议相反，发现灰黄霉素从固体分散体中的溶出速率明显受固体分散体粒径的影响。
