Akhmedov N A, Abbasova G D, Abbasly R M, Akhmedov N F
Rasulzade State University, Baku, Azerbaijan.
Bioorg Khim. 1998 Aug;24(8):586-92.
By means of conformational analysis, the spatial structure and conformational potential of the H-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-OH molecule, which corresponds to sequence 329-337 of the subunit 2 C-terminal region of the herpes virus ribonucleotide reductase, were studied. It was shown that its spatial organization can be described by a set of 17 low-energy conformations of the backbone. The "reverse conformational problem" for this molecule was solved to enable the prediction of a series of synthetic analogues matching the set of low-energy, potentially physiologically active conformations.
通过构象分析，研究了与疱疹病毒核糖核苷酸还原酶亚基2 C末端区域序列329 - 337相对应的H-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-OH分子的空间结构和构象潜能。结果表明，其空间组织可以用一组17种主链的低能构象来描述。解决了该分子的“反向构象问题”，以便预测一系列与低能、潜在生理活性构象集相匹配的合成类似物。
