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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

McKinnon R A, Nebert D W

Centre for Pharmaceutical Research, School of Pharmacy and Medical Sciences, South Australia, Adelaide, Australia.

Clin Exp Pharmacol Physiol. 1998 Oct;25(10):783-7. doi: 10.1111/j.1440-1681.1998.tb02153.x.

Despite the frenetic pace of cytochrome P450 (CYP) research, important questions remain about the possible role of xenobiotic-metabolizing CYP in development and cellular homeostasis. 2. The recent experimental development of CYP null mouse lines has provided valuable new models for addressing these issues, as well as providing novel in vivo models to study the precise role of CYP in chemical-mediated toxicity. 3. The present review summarizes results from the three Cyp gene knockout mouse lines generated so far and looks at likely future directions of this research field. 4. Also discussed are null mouse lines with targeted mutations in genes encoding receptors having primary roles in Cyp gene regulation.

尽管细胞色素P450（CYP）的研究进展迅速，但关于外源性物质代谢CYP在发育和细胞稳态中的可能作用仍存在重要问题。2. 最近CYP基因敲除小鼠品系的实验发展为解决这些问题提供了有价值的新模型，同时也为研究CYP在化学介导毒性中的精确作用提供了新的体内模型。3. 本综述总结了迄今为止产生的三种Cyp基因敲除小鼠品系的结果，并展望了该研究领域可能的未来方向。4. 还讨论了在编码在Cyp基因调控中起主要作用的受体的基因中具有靶向突变的基因敲除小鼠品系。

McKinnon R A, Nebert D W

Centre for Pharmaceutical Research, School of Pharmacy and Medical Sciences, South Australia, Adelaide, Australia.

Clin Exp Pharmacol Physiol. 1998 Oct;25(10):783-7. doi: 10.1111/j.1440-1681.1998.tb02153.x.

Despite the frenetic pace of cytochrome P450 (CYP) research, important questions remain about the possible role of xenobiotic-metabolizing CYP in development and cellular homeostasis. 2. The recent experimental development of CYP null mouse lines has provided valuable new models for addressing these issues, as well as providing novel in vivo models to study the precise role of CYP in chemical-mediated toxicity. 3. The present review summarizes results from the three Cyp gene knockout mouse lines generated so far and looks at likely future directions of this research field. 4. Also discussed are null mouse lines with targeted mutations in genes encoding receptors having primary roles in Cyp gene regulation.

尽管细胞色素P450（CYP）的研究进展迅速，但关于外源性物质代谢CYP在发育和细胞稳态中的可能作用仍存在重要问题。2. 最近CYP基因敲除小鼠品系的实验发展为解决这些问题提供了有价值的新模型，同时也为研究CYP在化学介导毒性中的精确作用提供了新的体内模型。3. 本综述总结了迄今为止产生的三种Cyp基因敲除小鼠品系的结果，并展望了该研究领域可能的未来方向。4. 还讨论了在编码在Cyp基因调控中起主要作用的受体的基因中具有靶向突变的基因敲除小鼠品系。