Jiang C L, Lu C L, Liu X Y
Department of Neurobiology, Second Military Medical University, Shanghai, P.R. China.
Domest Anim Endocrinol. 1998 Sep;15(5):363-9. doi: 10.1016/s0739-7240(98)00026-5.
IL-2 has analgesic effects in both central and peripheral nervous systems. There are two distinct domains in IL-2 molecule mediating immunologic and analgesic activity, respectively. The analgesic domain of IL-2 may be composed of the 44th Phe, 45th Tyr, 107th Tyr, and 117th Phe residues that are located closely in the tertiary structure of IL-2. The analgesic activity may be mediated through the analgesic domain interaction with opioid receptor. In addition to peptides, cytokines may directly bind to peptide receptors, other than their specific cytokine receptors themselves. Conversely, peptides may also interact with cytokine receptors. Thus, peptide neurotransmitters and hormones may serve as endogenous regulators of the immune system, and cytokines may also serve as neurotransmitters. Multiple actions might be mediated by interactions between distinct domains of bioactive molecules with different receptors.
白细胞介素-2在中枢和外周神经系统均具有镇痛作用。白细胞介素-2分子中有两个不同的结构域，分别介导免疫活性和镇痛活性。白细胞介素-2的镇痛结构域可能由第44位苯丙氨酸、第45位酪氨酸、第107位酪氨酸和第117位苯丙氨酸残基组成，这些残基在白细胞介素-2的三级结构中紧密相邻。镇痛活性可能是通过镇痛结构域与阿片受体的相互作用介导的。除了肽类，细胞因子可能直接与肽受体结合，而不是与它们自身特定的细胞因子受体结合。相反，肽类也可能与细胞因子受体相互作用。因此，肽类神经递质和激素可能作为免疫系统的内源性调节剂，而细胞因子也可能作为神经递质。生物活性分子不同结构域与不同受体之间的相互作用可能介导多种作用。
