Danon D, Madjar J, Edinov E, Knyszynski A, Brill S, Diamantshtein L, Shinar E
Center for Biology of Ageing, Weizmann Institute of Science, Rehovot, Israel.
Exp Gerontol. 1997 Nov-Dec;32(6):633-41. doi: 10.1016/s0531-5565(97)00094-6.
Decubital ulcers contribute to morbidity and mortality in elderly patients. Macrophages play a major role in the process of wound healing. We compared the efficacy of local treatment of decubital ulcers in elderly patients using macrophages prepared from a blood unit, vs. conventional treatments. Patients with decubital ulcers (n = 199) hospitalized during one year in a Geriatric Hospital in Israel, were included in the study. The ulcers of 72 patients (average age 82), who provided informed consent, by themselves or by family, were treated by local injection of macrophages prepared from a blood unit in a closed sterile system. The remaining 127 patients (average age 79) were treated conventionally and served as controls. No exclusion criteria were applied. Only a completely healed ulcer was considered a positive outcome of treatment. In the macrophage-treated group 27% (36 out of 131 ulcers) were healed compared to 6% (15 out of 248) in the control group (p < 0.001). There was also a significantly faster healing in the experimental group (p < 0.02). No side effects were noted. We conclude that Macrophages prepared from a blood unit, in cost-effective, closed, sterile system, are significantly more effective than conventional methods for the treatment of ulcers in elderly patients.
褥疮溃疡会导致老年患者发病和死亡。巨噬细胞在伤口愈合过程中起主要作用。我们比较了使用从一个血液单位制备的巨噬细胞对老年患者褥疮溃疡进行局部治疗与传统治疗的效果。纳入研究的患者为在以色列一家老年医院住院一年的199例褥疮溃疡患者。72例患者（平均年龄82岁），经本人或家属签署知情同意书后，其溃疡通过在封闭无菌系统中局部注射从一个血液单位制备的巨噬细胞进行治疗。其余127例患者（平均年龄79岁）接受传统治疗并作为对照。未应用排除标准。只有完全愈合的溃疡才被视为治疗的阳性结果。巨噬细胞治疗组中27%（131个溃疡中的36个）愈合，而对照组为6%（248个溃疡中的15个）（p<0.001）。实验组愈合速度也明显更快（p<0.02）。未观察到副作用。我们得出结论，在经济高效的封闭无菌系统中从一个血液单位制备的巨噬细胞，在治疗老年患者溃疡方面比传统方法显著更有效。
