Vorob'eva L I, Cherdyntseva T A
Moscow State University, Russia.
Mikrobiologiia. 1998 Jul-Aug;67(4):522-6.
The resistance of Enterococcus faecalis to exposure to 4-nitroquinoline-1-oxide (4-NQO) as well as to UV irradiation and nalidixic acid was shown to increase as a result of reinoculations in medium containing 4-NQO. Irradiation of cells with UV254 (20, 60, or 100 J/m2) did not increase their resistance to 4-NQO. The desmutagenic activity of 4-NQO-adapted cells in the case of mutagenesis induced by 4-NQO was higher than in control cells. The mechanism of induced resistance is discussed.
粪肠球菌对4-硝基喹啉-1-氧化物（4-NQO）、紫外线照射和萘啶酸的抗性因在含4-NQO的培养基中多次传代培养而增强。用UV254（20、60或100 J/m2）照射细胞并未增强其对4-NQO的抗性。在由4-NQO诱导的诱变情况下，适应4-NQO的细胞的去诱变活性高于对照细胞。本文讨论了诱导抗性的机制。
