内皮素-1在肝硬化患者的肾功能中起作用吗？
Does endothelin-1 play a role in the renal function of cirrhotic patients?
作者信息
Bruno C M, D'Amico R, Ierna D, Neri S
机构信息
Institute of Internal and Emergency Medicine, University of Catania, Italy.
出版信息
Panminerva Med. 1998 Sep;40(3):196-8.
METHODS
We investigated plasma and urinary endothelin-1 levels in eleven cirrhotic patients and ten healthy control subjects, to evaluate whether endothelin is involved in renal functional alterations of liver cirrhosis.
RESULTS
No significant difference in plasma ET-1 levels was observed between the two groups (p > 0.05) but urinary ET-1 excretion was significantly higher in cirrhotics than in controls (p < 0.001). Creatinine clearance (mean 56 +/- 7.6 ml/min) showed an inverse correlation with plasma ET-1 levels (p < 0.05) in cirrhotics.
CONCLUSIONS
We believe this may be caused by enhanced local ET-1 activity linked to an up-regulation of its specific receptors and/or increased renal synthesis, resulting in augmented urinary excretion.
方法
我们对11例肝硬化患者和10名健康对照者的血浆和尿内皮素-1水平进行了研究，以评估内皮素是否参与肝硬化患者的肾功能改变。
结果
两组间血浆ET-1水平无显著差异（p>0.05），但肝硬化患者的尿ET-1排泄量显著高于对照组（p<0.001）。肝硬化患者的肌酐清除率（平均56±7.6 ml/min）与血浆ET-1水平呈负相关（p<0.05）。
结论
我们认为这可能是由于局部ET-1活性增强，与其特异性受体上调和/或肾脏合成增加有关，导致尿排泄增加。
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