Winfree A T
University of Arizona, Tucson 85721, USA.
Prog Biophys Mol Biol. 1998;69(2-3):185-203. doi: 10.1016/s0079-6107(98)00007-8.
In the United States among males 20-64 years old about 1/3 of deaths are classified as 'sudden cardiac death', and 1/4 had no forewarning, nor did autopsy turn up any visible cause. The heart just switches from its normally periodic pumping to an alternative mode called 'fibrillation' more resembling electrical turbulence. In normal tissue its mechanism is a geometrically re-entrant mode of normal propagation. Everything about this spatial pattern depends upon the magnitude of 'D', the one term with dimension involving space in the pertinent biophysical equations. Explicit or implicit estimates in current literature span orders of magnitude. In this article I argue from a diversity of recent experiments for a narrower range of realistic values. It has an important role in the spatio-temporal evolution of fibrillation and in defibrillation.
在美国，20至64岁的男性中，约三分之一的死亡被归类为“心源性猝死”，四分之一的人没有任何预警，尸检也未发现任何明显病因。心脏只是从正常的周期性泵血模式转变为另一种称为“颤动”的模式，更类似于电流紊乱。在正常组织中，其机制是正常传播的几何再入模式。这种空间模式的一切都取决于“D”的大小，“D”是相关生物物理方程中涉及空间维度的唯一一项。当前文献中的显式或隐式估计跨越了几个数量级。在本文中，我根据最近的一系列实验，主张一个更窄范围的现实值。它在颤动的时空演变和除颤中起着重要作用。
