Hansen J J, Feilberg Jørgensen N H
Odense Universitetshospital, børneafdeling H.
Ugeskr Laeger. 1998 Oct 5;160(41):5946-7.
Cetirizine is a commonly used non-sedating antihistamine for the symptomatic relief of allergic reactions. Few reports exist on the result of overdose in children. We would like to report the result of a 12 fold overdose of cetirizine in a four-year-old-boy (weight 20 kg) who accidentally ingested 60 mg. Vomiting was induced 1 1/2 hour after ingestion in the out-patient clinic at the local hospital because of severe drowsiness. Due to continued lethargy he was transferred to the referral paediatric department for further observation. He was fully recovered after five to six hours without any treatment. Electrocardiographic monitoring was normal. Five incidents of cetirizine overdose in children have been reported previously. Drowsiness and sedation were observed, but no other side effects. The risk of cardiac events related to an overdose of cetirizine is extremely small. A certain degree of sedation is to be expected.
西替利嗪是一种常用的非镇静性抗组胺药，用于缓解过敏反应的症状。关于儿童过量服用西替利嗪的结果的报道很少。我们想报告一名4岁男孩（体重20公斤）意外摄入60毫克西替利嗪，服用剂量为正常剂量12倍的情况。因严重嗜睡，在当地医院门诊摄入药物1个半小时后诱导其呕吐。由于持续嗜睡，他被转至转诊儿科进一步观察。未经任何治疗，五六个小时后他完全康复。心电图监测正常。此前已报道过5例儿童过量服用西替利嗪的事件。观察到有嗜睡和镇静作用，但无其他副作用。与过量服用西替利嗪相关的心脏事件风险极小。出现一定程度的镇静作用是可以预料的。
