Wunderlich R P, Peters E J, Bosma J, Armstrong D G
Department of Orthopaedics, University of Texas Health Science Center at San Antonio, USA.
South Med J. 1998 Oct;91(10):894-8. doi: 10.1097/00007611-199810000-00001.
Symptomatic peripheral neuropathy is the most common complication of diabetes mellitus, affecting up to 62% of Americans with diabetes.
We reviewed the literature using the National Library of Medicine's MEDLINE search service. In total, we reviewed 54 articles.
Hyperglycemia leads to increased activity in the polyol pathway in nerve cells; this ultimately results in abnormal nerve function. Numerous pharmacologic agents have been used to treat symptomatic peripheral neuropathy, but all of these drugs can be associated with adverse side effects. Recent work has indicated that subsensory electrical stimulation may be preferred to pharmacotherapy, since it is equally effective and has a more favorable safety profile.
Although the pathophysiology of diabetic neuropathy is well understood, treatment of the symptoms associated with this condition can be challenging. Additional research is needed to reveal a safe and effective treatment for this debilitating sequela of diabetes mellitus.
症状性周围神经病变是糖尿病最常见的并发症，影响多达62%的美国糖尿病患者。
我们使用美国国立医学图书馆的MEDLINE检索服务对文献进行了综述。我们总共查阅了54篇文章。
高血糖会导致神经细胞中多元醇途径的活性增加；这最终会导致神经功能异常。许多药物已被用于治疗症状性周围神经病变，但所有这些药物都可能伴有不良副作用。最近的研究表明，亚感觉电刺激可能比药物治疗更可取，因为它同样有效且安全性更高。
尽管糖尿病神经病变的病理生理学已得到充分了解，但治疗与此病症相关的症状仍具有挑战性。需要进一步的研究来揭示一种针对糖尿病这种使人衰弱的后遗症的安全有效的治疗方法。
