Dikov D I, Roland J, Chatelet F P, Cywiner-Golenzer C
Department of Pathology, Rothschild Hospital, Paris, France.
Arch Pathol Lab Med. 1998 Oct;122(10):875-9.
We describe a combination of epithelial cell apoptosis and intracytoplasmic inclusions in prostatic epithelium in 6 patients who died from the acquired immunodeficiency syndrome. Two different types of apoptosis were detected: simple cell shrinkage and exploding glandular cells. No intracellular or extracellular viral particles were detected, either ultrastructurally or immunohistochemically. Intracytoplasmic inclusions are apoptotic bodies in a state of degradation and in close association with lipofuscin. The cell degeneration we observed confirms the theory that increased apoptotic cell depletion is responsible for weight loss in the acquired immunodeficiency syndrome. In the prostate itself, the combination of excessive apoptosis and active phagosomal digestion of apoptotic bodies presents a "human model" of postcastration rat ventral prostate, under the conditions of severe immune deficiency.
我们描述了6例死于获得性免疫缺陷综合征患者前列腺上皮细胞凋亡与胞质内包涵体的组合情况。检测到两种不同类型的凋亡：单纯细胞皱缩和腺细胞爆炸样改变。超微结构或免疫组织化学检测均未发现细胞内或细胞外病毒颗粒。胞质内包涵体是处于降解状态且与脂褐素密切相关的凋亡小体。我们观察到的细胞变性证实了以下理论，即凋亡细胞过度消耗导致获得性免疫缺陷综合征患者体重减轻。在前列腺本身，过度凋亡与凋亡小体的活跃吞噬消化相结合，在严重免疫缺陷的情况下呈现出去势大鼠腹侧前列腺的“人体模型”。
