Dunphy C H, Lattuada C P
Department of Pathology, St Louis (MO) University Health Sciences Center, 63104, USA.
Arch Pathol Lab Med. 1998 Oct;122(10):936-8.
Follicular center cell lymphomas often contain a prominent population of T cells, most commonly in the interfollicular regions and with a helper immunophenotype. We report a case of follicular center cell lymphoma (follicular, mixed cell types) with a prominent population of T cells (normal CD4-CD8 ratio) in both the interfollicular and follicular regions. The prominent T-cell population resulted in misleading flow cytometric immunophenotypic findings. Immunoperoxidase stains (L-26, LN-2, and Bcl-2) confirmed the neoplastic follicular center cell origin and aided in subclassification.
滤泡中心细胞淋巴瘤通常含有大量T细胞，最常见于滤泡间区，具有辅助性免疫表型。我们报告一例滤泡中心细胞淋巴瘤（滤泡型，混合细胞类型），在滤泡间区和滤泡区均有大量T细胞（正常CD4-CD8比值）。显著的T细胞群体导致流式细胞术免疫表型结果产生误导。免疫过氧化物酶染色（L-26、LN-2和Bcl-2）证实了肿瘤性滤泡中心细胞的起源，并有助于进行亚分类。
