Assessment of regional differences in intestinal fluid movement in the rat using a modified in situ single pass perfusion model.

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作者信息

Raoof A A, Butler J, Devane J G

机构信息

IVIVR Cooperative Working Group, Elan Pharmaceutical Technologies, Athlone, Ireland.

出版信息

Pharm Res. 1998 Aug;15(8):1314-6. doi: 10.1023/a:1011920714784.

DOI:10.1023/a:1011920714784

PMID:9786780

Abstract

摘要

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本文引用的文献

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Am J Dig Dis. 1962 Jan;7:17-27. doi: 10.1007/BF02231926.

Comparison of methodologies for evaluating regional intestinal permeability.评估区域肠道通透性方法的比较

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Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms.具有不同物理化学性质和转运机制的化合物对大鼠肠道区域通透性的影响

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Comparison between permeability coefficients in rat and human jejunum.大鼠与人类空肠渗透系数的比较。

Pharm Res. 1996 Sep;13(9):1336-42. doi: 10.1023/a:1016065715308.

Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?肠道黏膜间的液体流动会影响口服药物的定量吸收吗？是否到了重新评估的时候？

Pharm Res. 1995 Nov;12(11):1573-82. doi: 10.1023/a:1016220428705.

Influence of anesthetic regimens on intestinal absorption in rats.麻醉方案对大鼠肠道吸收的影响。

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