Kimble J, Henderson S, Crittenden S
Dept of Biochemistry, University of Wisconsin-Madison, USA.
Trends Biochem Sci. 1998 Sep;23(9):353-7. doi: 10.1016/s0968-0004(98)01263-8.
Intercellular signaling through the Notch/LIN-12 transmembrane receptors regulates growth and differentiation during animal development. Moreover, defects in the conserved Notch/LIN-12 pathway are linked to human diseases. Here, we review models for two key steps in Notch/LIN-12 signaling: ligand-mediated activation of the receptor and receptor-mediated activation of transcription. Ligand binding appears to permit proteolysis of the receptor; as a result, the receptor's intracellular domain can enter the nucleus and function as a transcriptional co-activator.
通过Notch/LIN-12跨膜受体进行的细胞间信号传导在动物发育过程中调节生长和分化。此外，保守的Notch/LIN-12信号通路中的缺陷与人类疾病有关。在这里，我们综述了Notch/LIN-12信号传导中两个关键步骤的模型：配体介导的受体激活和受体介导的转录激活。配体结合似乎允许受体进行蛋白水解；结果，受体的细胞内结构域可以进入细胞核并作为转录共激活因子发挥作用。
