lin-12/Notch蛋白的结构/功能研究

Structure/function studies of lin-12/Notch proteins.

作者信息

Greenwald I

机构信息

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032.

出版信息

Curr Opin Genet Dev. 1994 Aug;4(4):556-62. doi: 10.1016/0959-437x(94)90072-b.

DOI:10.1016/0959-437x(94)90072-b

PMID:7950324

Abstract

The lin-12/Notch proteins appear to act as transmembrane receptors for intercellular signals that specify cell fates during animal development. Recent structure/function studies have shown that the lin-12/Notch intracellular domain alone has the intrinsic signal-transducing activity of the intact protein, and that the role of the extracellular domain is to regulate this intrinsic activity. These studies have also suggested that the different lin-12/Notch proteins in a given organism are interchangeable biochemically and have addressed the role of lin-12/Notch genes in development.

摘要

lin-12/Notch蛋白似乎作为细胞间信号的跨膜受体，在动物发育过程中决定细胞命运。最近的结构/功能研究表明，仅lin-12/Notch细胞内结构域就具有完整蛋白的内在信号转导活性，而细胞外结构域的作用是调节这种内在活性。这些研究还表明，给定生物体中的不同lin-12/Notch蛋白在生化上是可互换的，并探讨了lin-12/Notch基因在发育中的作用。