Pendergrast W J, Drake W P, Mardiney M R
J Natl Cancer Inst. 1976 Sep;57(3):539-44. doi: 10.1093/jnci/57.3.539.
The therapeutic effectiveness of surgery, chemotherapy, and immunotherapy alone and in combination were studied in the B16 melanoma model. The sequence of chemotherapy and immunotherapy as adjuvants to surgery proved important: Chemotherapy was significantly better when given before surgery; immunotherapy was more effective when delivered after surgery. The most effective therapeutic regimen was a combination of all three modalities: a single course of chemotherapy preceding surgery followed by immunotherapy.
在B16黑色素瘤模型中研究了单独及联合使用手术、化疗和免疫疗法的治疗效果。化疗和免疫疗法作为手术辅助手段的顺序被证明很重要：术前给予化疗效果显著更好；术后给予免疫疗法更有效。最有效的治疗方案是三种方式联合：术前进行一个疗程的化疗，然后进行免疫疗法。
