Best P J, Petitt R M
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic Rochester, Minnesota 55905, USA.
Mayo Clin Proc. 1998 Oct;73(10):961-3. doi: 10.4065/73.10.961.
The association of multiple cutaneous cancers and long-term use of hydroxyurea is now being recognized. In this article, we describe the development of multiple skin tumors in two patients who were receiving hydroxyurea therapy. These cases illustrate the late onset of subsequent skin cancers despite discontinuation of therapy. As hydroxyurea continues to have a prominent role in the treatment of myeloproliferative diseases, clinicians must be aware of the increased risk of multiple skin cancers and use preventive and skin cancer screening practices in patients with these diseases.
多发性皮肤癌与长期使用羟基脲之间的关联如今正逐渐被认识到。在本文中，我们描述了两名接受羟基脲治疗的患者发生多发性皮肤肿瘤的情况。这些病例表明，尽管停止了治疗，但后续皮肤癌仍会延迟发生。由于羟基脲在骨髓增殖性疾病的治疗中仍发挥着重要作用，临床医生必须意识到多发性皮肤癌风险的增加，并对患有这些疾病的患者采取预防措施和进行皮肤癌筛查。
