吉非贝齐可降低喂食高胆固醇饮食的外源性高胆固醇血症（ExHC）大鼠的非高密度脂蛋白胆固醇水平。

Gemfibrozil reduces non-high-density lipoprotein cholesterol in exogenously hypercholesterolemic (ExHC) rats fed a high-cholesterol diet.

作者信息

Nagao K, Yoshida S, Nakagiri H, Sakono M, Sato M, Imaizumi K

机构信息

Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

出版信息

Comp Biochem Physiol B Biochem Mol Biol. 1998 Jul;120(3):579-86. doi: 10.1016/s0305-0491(98)10049-4.

DOI:10.1016/s0305-0491(98)10049-4

PMID:9787818

Abstract

Gemfibrozil is a widely used drug prescribed to elevate serum high-density lipoprotein (HDL) cholesterol levels and lower triacylglycerols. The present study was done to determine if the drug would alleviate hypercholesterolemia in exogenously hypercholesterolemic (ExHC) rats. In the drug-treated ExHC rats, the serum non-HDL cholesterol levels were lowered and the ratio of the non HDL cholesterol to serum triacylglycerols was decreased to the extent seen in the drug-treated SD rats. Liver cholesterol and triacylglycerols were lowered in the drug-treated rats. There was also an increase in fecal excretion of neutral sterols and bile acids, particularly chenodeoxycholic and beta-muricholic acids. The drug elevated cholesterol 7 alpha-hydroxylase activity and mRNA abundance and acyl-CoA cholesterol acyltransferase activity in the liver, but did not influence low-density lipoprotein receptor mRNA level in the liver. Thus, gemfibrozil is effective in alleviating hypercholesterolemia in exogenously hypercholesterolemic rats, by partitioning hepatic cholesterol into biliary excretion.

摘要

吉非贝齐是一种广泛使用的药物，用于提高血清高密度脂蛋白（HDL）胆固醇水平并降低三酰甘油。本研究旨在确定该药物是否能缓解外源性高胆固醇血症（ExHC）大鼠的高胆固醇血症。在接受药物治疗的ExHC大鼠中，血清非HDL胆固醇水平降低，非HDL胆固醇与血清三酰甘油的比率降至与接受药物治疗的SD大鼠相同的程度。接受药物治疗的大鼠肝脏胆固醇和三酰甘油含量降低。中性固醇和胆汁酸的粪便排泄也增加，特别是鹅去氧胆酸和β-鼠胆酸。该药物提高了肝脏中胆固醇7α-羟化酶活性、mRNA丰度以及酰基辅酶A胆固醇酰基转移酶活性，但不影响肝脏中低密度脂蛋白受体mRNA水平。因此，吉非贝齐通过将肝脏胆固醇分配到胆汁排泄中，有效缓解了外源性高胆固醇血症大鼠的高胆固醇血症。