Takasaki T, Akiba S, Sagara Y, Yoshida H
Department of Pathology, Faculty of Medicine, Kogoshima University, Japan.
Pathol Int. 1998 Oct;48(10):800-5. doi: 10.1111/j.1440-1827.1998.tb03840.x.
Fifty-two mammary carcinomas, 2 cm or less in diameter, were examined in order to clarify the morphology and biology of microinvasion. The morphological characteristics of microinvasion of carcinomas include: (i) a loss of myoepithelial cells and a rupture with concomitant loss of collagen IV and laminin in the basement membrane of involved mammary glands; and (ii) budding of carcinomas from the rupture into the stroma. When microinvasion was defined as a rupture of < 200 microm in the basement membrane with invasion, the number of microinvasions per 1 mm of basement membrane was larger in the tumors in which the area of invasion was larger. The prevalence of microinvasion showed a significant correlation with lymph node metastasis and the rate of histological deviation, while no correlation of expression of either estrogen receptors or progesterone receptors and c-erbB-2 protein was found. The study clarified that the early invasion of mammary carcinomas could be detected by the immunohistochemical method using anti-smooth muscle actin, laminin and collagen IV antibodies. The study also suggested that microinvasion might be an indicator of lymph node metastasis in mammary carcinomas < or = 2 cm diameter.
为阐明微浸润的形态学和生物学特征，对52例直径2 cm及以下的乳腺癌进行了检查。癌微浸润的形态学特征包括：(i) 肌上皮细胞缺失，受累乳腺基底膜中的IV型胶原和层粘连蛋白随之破裂并丢失；(ii) 癌从破裂处向间质出芽。当微浸润定义为基底膜破裂且浸润＜200微米时，每1毫米基底膜的微浸润数量在浸润面积较大的肿瘤中更多。微浸润的发生率与淋巴结转移及组织学偏离率显著相关，而未发现雌激素受体、孕激素受体或c-erbB-2蛋白的表达存在相关性。该研究表明，使用抗平滑肌肌动蛋白、层粘连蛋白和IV型胶原抗体的免疫组化方法可检测到乳腺癌的早期浸润。该研究还提示，微浸润可能是直径≤2 cm乳腺癌淋巴结转移的一个指标。
