Masters C, Crane D
The School of Biomolecular and Biomedical Science, Griffith University, Brisbane, Nathan, Australia.
Mol Cell Biochem. 1998 Oct;187(1-2):85-97. doi: 10.1023/a:1006863123068.
This article reviews the currently available data on the role of peroxisomal function in relation to the processes of cell differentiation and carcinogenesis. In regard to tumourigenesis, both genotoxic and non-genotoxic processes have been considered, and the peroxisomal relationships with these phenomena and with differentiation are described at the level of organelle characteristics, enzyme contents, and the involvement of retinoids, steroid hormones, oxygen free radicals, growth factors, apoptosis, omega-3 polyunsaturated fatty acids and the cellular signalling networks. Overall these data serve to illustrate the unique and distinctive role of the peroxisome in differentiation and carcinogenesis, and point to the advantages of considering the peroxisomal involvement in the holistic context of the differentiation dedifferentiation continuum rather than the narrower focus of non-genotoxic carcinogenesis. The review also outlines the potential for medical benefit arising from a fuller understanding of these peroxisomal affiliations.
本文综述了目前有关过氧化物酶体功能在细胞分化和致癌过程中作用的现有数据。关于肿瘤发生，已考虑了基因毒性和非基因毒性过程，并从细胞器特征、酶含量以及类视黄醇、类固醇激素、氧自由基、生长因子、细胞凋亡、ω-3多不饱和脂肪酸和细胞信号网络的参与等层面描述了过氧化物酶体与这些现象以及与分化的关系。总体而言，这些数据有助于阐明过氧化物酶体在分化和致癌过程中的独特作用，并指出在分化-去分化连续统一体的整体背景下考虑过氧化物酶体参与的优势，而非局限于非基因毒性致癌的较狭隘关注点。该综述还概述了更全面了解这些过氧化物酶体联系可能带来的医学益处。
