双螺旋DNA中磷酸基团的水合作用。
Hydration of the phosphate group in double-helical DNA.
作者信息
Schneider B, Patel K, Berman H M
机构信息
J. Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, CZ-18223 Prague, Czech Republic.
出版信息
Biophys J. 1998 Nov;75(5):2422-34. doi: 10.1016/S0006-3495(98)77686-6.
Abstract
Water distributions around phosphate groups in 59 B-, A-, and Z-DNA crystal structures were analyzed. It is shown that the waters are concentrated in six hydration sites per phosphate and that the positions and occupancies of these sites are dependent on the conformation and type of nucleotide. The patterns of hydration that are characteristic of the backbone of the three DNA helical types can be attributed in part to the interactions of these hydration sites.
摘要
分析了59种B型、A型和Z型DNA晶体结构中磷酸基团周围的水分布情况。结果表明，每个磷酸基团周围的水集中在六个水合位点，且这些位点的位置和占有率取决于核苷酸的构象和类型。这三种DNA螺旋类型主链特有的水合模式部分可归因于这些水合位点的相互作用。
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