Tokui T, Takao M, Shimamoto A, Fujinaga K, Yasuda F, Gan K, Gun R, Shimono T, Namikawa S, Yada I
Department of Thoracic and Cardiovascular Surgery, Mie University School of Medicine, Tsu, Japan.
Kyobu Geka. 1998 Oct;51(11):915-20.
We reviewed pT3 lung cancer for 86 cases (13.1%) out of 659 cases treated surgically for primary lung cancer between 1985 and march 1998. Five-year and ten-year survival rates for all pT3 cases were 48% and 40% respectively and those for pT3N0M0 cases were 67.2%. The operative mortality between 1990 and 1998 (2.4%) was better than that between 1985 and 1989 (6.7%). The extensive resection for pT3 lung cancer was evaluated to be appropriate. However, the prognosis of the patients who underwent combined resection of mediastinal pleura, pericardium or diaphragm was very poor. Five-year survival rate was significantly worse in patients with N2 disease (17.3%) than in patients with N0 disease (65.8%) (p < 0.05). Although the surgical indication for the patients with mediastinal pleura, pericardium or diaphragm disease and N2 disease is still controversial, there is not the extensive surgical indication.
我们回顾了1985年至1998年3月间接受原发性肺癌手术治疗的659例患者中的86例（13.1%）pT3期肺癌患者。所有pT3期病例的5年和10年生存率分别为48%和40%，pT3N0M0病例的5年和10年生存率分别为67.2%。1990年至1998年的手术死亡率（2.4%）低于1985年至1989年（6.7%）。评估认为对pT3期肺癌进行广泛切除是合适的。然而，接受纵隔胸膜、心包或膈肌联合切除的患者预后很差。N2期疾病患者的5年生存率（17.3%）明显低于N0期疾病患者（65.8%）（p<0.05）。尽管对于纵隔胸膜、心包或膈肌疾病以及N2期疾病患者的手术指征仍存在争议，但尚无广泛的手术指征。
