Maniwa Y, Okada M, Yamamoto H
Department of Surgery, Kobe University School of Medicine, Japan.
Kyobu Geka. 1998 Oct;51(11):939-43.
Surgical intervention is routinely employed for non-small cell lung cancer, whenever no distant metastasis is found. However, its surgical results depend on the staging of the lung cancer, and surgery for stage III disease is less effective compared with stage I or II disease. For patients with stage III, some treatments such as induction chemotherapy have been tried to support the surgery. Recently, T3 lung cancer is divided in two category of staging, T3N0 is evaluated to be stage II B and T3N1-2 is stage III A. In this study, we classified T3 diseases by some factors, and examined long-term survival of each group. As a result, we concluded that mediastinal invasion and N2 involvement were risk factors to early failure. On the contrary, patients with adjacent lobe invasion and resection of two lobes led to the prolonged survival rather than lobectomy with partial resection of adjacent lobe.
只要未发现远处转移，手术干预通常用于非小细胞肺癌。然而，其手术结果取决于肺癌的分期，与I期或II期疾病相比，III期疾病的手术效果较差。对于III期患者，已尝试一些治疗方法如诱导化疗来辅助手术。最近，T3期肺癌被分为两个分期类别，T3N0被评估为II B期，T3N1 - 2为III A期。在本研究中，我们根据一些因素对T3期疾病进行分类，并检查每组的长期生存率。结果，我们得出结论，纵隔侵犯和N2受累是早期失败的危险因素。相反，伴有相邻肺叶侵犯且行两肺叶切除的患者比行肺叶切除并部分切除相邻肺叶的患者生存期更长。
