人类基因组中存在的内源性逆转录病毒序列
[Endogenous retroviral sequences present in the human genome].
作者信息
Kubiatowski T, Gasowska-Giszczak U, Grabek-Gawłowicz M, Wojcierowski J
机构信息
Zakład Genetyki Medycznej Akademii Medycznej w Lublinie.
出版信息
Postepy Hig Med Dosw. 1998;52(3):223-35.
The human genome contains a variety of elements resembling mammalian retroviruses. Most of these sequences are related to primate, murine C-types viruses, murine B-type viruses and A-type particles or HTLV. These sequences comprise at least 0.1-0.6% of human genome. They are transcriptionally active especially in human placenta, embryonic tissue and in human tumor cell lines. Endogenous retroviruses and retroviral elements represent a cellular reservoir of possibly pathogenic retroviral genes.
人类基因组包含多种类似于哺乳动物逆转录病毒的元件。这些序列大多与灵长类、鼠类C型病毒、鼠类B型病毒、A型颗粒或人类嗜T淋巴细胞病毒相关。这些序列至少占人类基因组的0.1 - 0.6%。它们具有转录活性，尤其在人类胎盘、胚胎组织和人类肿瘤细胞系中。内源性逆转录病毒和逆转录病毒元件代表了可能具有致病性的逆转录病毒基因的细胞储存库。
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