Brissaud O, Pedespan J M, Chateil J F, Loiseau H, Dautheribes M, Wardi Y, Brun M, Rougier A
Unité de neurologie pédiatrique, hôpital des enfants Pellegrin, Bordeaux, France.
Arch Pediatr. 1998 Sep;5(9):959-64. doi: 10.1016/s0929-693x(98)80002-x.
Gangliogliomas belong to debated nosological entity. They are classified as neuronal or neuroglial tumors.
Six children aged from 4 months to 15 years (mean age: 4 years and 6 months) were initially seen for partial seizures resistant to treatment. Tumoral resection was performed in all six. Diagnosis was made from immunohistological study of the tumor.
Gangliogliomas are non-malignant, with a good prognosis, even if inaugural clinical manifestations are severe. Neuroradiological diagnosis with astrocytomas and cortical dysplasia is not easy, and pathological distinction from cortical dysplasia is difficult.
The immunohistochemical confirmation of diagnosis permits a logical therapeutic attitude: complete resection of tumor is followed by an excellent outcome.
神经节胶质瘤属于存在争议的疾病实体。它们被归类为神经元或神经胶质肿瘤。
6名年龄从4个月至15岁（平均年龄：4岁6个月）的儿童最初因治疗抵抗性部分性癫痫发作前来就诊。所有6例均进行了肿瘤切除。通过肿瘤的免疫组织学研究做出诊断。
神经节胶质瘤为非恶性，预后良好，即便初始临床表现严重。与星形细胞瘤和皮质发育异常进行神经放射学诊断并不容易，且与皮质发育异常进行病理鉴别也很困难。
诊断的免疫组化确认允许采取合理的治疗态度：肿瘤完全切除后预后极佳。
