Brown E S, Dilsaver S C, Bowers T C, Swann A C
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9070, USA.
Clin Neuropharmacol. 1998 Sep-Oct;21(5):316-8.
There is little information in the literature concerning the use of droperidol in psychiatry. This article presents three cases in which extremely agitated and treatment-refractory persons with mixed mania derived benefit from droperidol administered orally. Symptomatic improvement, including decreased agitation and intrusiveness, improved sleep, and decreased rates of sleep, was observed with the use of oral droperidol at doses ranging from 10-80 mg daily. The only adverse reaction was a dystonia in one patient. This article also reviews the limited available literature on the use of droperidol in psychiatry. Only eight English language articles describing the use of droperidol for psychosis or agitation were found. Future controlled studies to examine the usefulness of oral dosing of droperidol in mania are suggested.
文献中关于氟哌利多在精神病学中的应用的信息很少。本文介绍了三例极度烦躁且对治疗难治的混合性躁狂患者，口服氟哌利多后从中获益的案例。使用每日剂量为10 - 80毫克的口服氟哌利多后，观察到症状有所改善，包括烦躁和侵扰行为减少、睡眠改善以及睡眠时间缩短。唯一的不良反应是一名患者出现了肌张力障碍。本文还回顾了关于氟哌利多在精神病学中应用的有限现有文献。仅发现八篇描述氟哌利多用于治疗精神病或烦躁的英文文章。建议未来进行对照研究，以检验口服氟哌利多治疗躁狂的有效性。
