Jazwinski S M, Kim S, Lai C Y, Benguria A
Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA.
Exp Gerontol. 1998 Sep;33(6):571-80. doi: 10.1016/s0531-5565(98)00029-1.
Aging is a complex process. It consists of a diverse assortment of seemingly random manifestations that occur in the individual, the mutual relationship and impact on mortality of which is frequently obscure. We derive a simple equation to model the aging process based on scale invariant and increasing change. The solution to this equation indicates that this change itself, irrespective of its quality, is the cause and not simply the effect of aging. This model establishes loss of homeostasis as a fundamental feature of aging. The model is deterministic, but it supports the stochastic nature of age changes. Paradoxically, this model states that a sufficient augmentation of aging processes results in a lack of aging. Experimental evidence in support of this model is presented that spans the levels of population mortality rates, cellular spatial organization, and gene dysregulation.
衰老过程复杂，由个体身上出现的各种看似随机的表现组成，这些表现之间的相互关系及其对死亡率的影响往往模糊不清。我们基于尺度不变性和递增变化推导出一个简单方程来模拟衰老过程。该方程的解表明，这种变化本身，无论其性质如何，都是衰老的原因而非仅仅是衰老的结果。此模型将内稳态的丧失确立为衰老的一个基本特征。该模型是确定性的，但它支持年龄变化的随机性。矛盾的是，该模型表明衰老过程的充分增强会导致衰老的缺失。本文展示了支持该模型的实验证据，这些证据涵盖了人口死亡率、细胞空间组织和基因失调等层面。
