Janssens Georges E, Veenhoff Liesbeth M
European Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Microb Cell. 2016 Jun 20;3(7):263-274. doi: 10.15698/mic2016.07.510.
Recently, efforts have been made to characterize the hallmarks that accompany and contribute to the phenomenon of aging, as most relevant for humans 1. Remarkably, studying the finite lifespan of the single cell eukaryote budding yeast (recently reviewed in 2 and 3) has been paramount for our understanding of aging. Here, we compile observations from literature over the past decades of research on replicatively aging yeast to highlight how the hallmarks of aging in humans are present in yeast. We find strong evidence for the majority of these, and summarize how yeast aging is especially characterized by the hallmarks of genomic instability, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, and mitochondrial dysfunction.
最近，人们致力于描述伴随衰老现象并导致衰老现象的特征，这些特征对人类最为相关1。值得注意的是，研究单细胞真核生物出芽酵母的有限寿命（最近在2和3中进行了综述）对于我们理解衰老至关重要。在这里，我们汇总了过去几十年关于复制性衰老酵母研究的文献观察结果，以突出人类衰老特征在酵母中的体现。我们发现了其中大多数特征的有力证据，并总结了酵母衰老如何特别以基因组不稳定、表观遗传改变、蛋白质稳态丧失、营养感应失调和线粒体功能障碍等特征为特点。
