Saito Y, Lee Y S, Kimura S
Bio Science Laboratories, Meiji Seika Kaisha, Ltd., Saitama, Japan.
Int J Vitam Nutr Res. 1998;68(5):335-40.
We examined the effect of ingested casein phosphopeptides (CPP) on intestinal calcium (Ca) absorption and determined the minimum effective dose for enhancement of Ca absorption under conditions of marginal dietary Ca levels. Male Sprague-Dawley rats, divided upon weaning into five groups, were fed a control diet (isolated soyprotein, ISP; 20%) or a CPP diet (ISP + CPP; 20%, CPP/Ca: 0.1, 0.2, 0.35 and 1.0) for 4 weeks. All diets contained the same amounts of Ca (0.35%) and phosphorus (0.70%). The apparent Ca absorption, the retention of Ca, and the luminal soluble Ca content in the small intestine as determined at 4 weeks in the rats fed CPP diet with a weight ratio of CPP/Ca of more than 0.2 were significantly (p < 0.05) higher than those in the rats fed control diet. The wet weight, length and Ca content of the femur were not significantly different among the groups. These results indicate that the minimum effective dose of CPP for enhancement of Ca absorption is 0.7 g/kg or a weight ratio of CPP/Ca of 0.2 in the ISP diet and that CPP supplementation has the effect of significantly increasing Ca absorption at least under conditions of marginal dietary Ca levels.
我们研究了摄入的酪蛋白磷酸肽（CPP）对肠道钙（Ca）吸收的影响，并确定了在膳食钙水平较低的情况下增强钙吸收的最小有效剂量。将雄性Sprague-Dawley大鼠在断奶时分为五组，分别喂食对照饮食（分离大豆蛋白，ISP；20%）或CPP饮食（ISP + CPP；20%，CPP/Ca：0.1、0.2、0.35和1.0），持续4周。所有饮食中的钙（0.35%）和磷（0.70%）含量相同。在喂食CPP/Ca重量比大于0.2的饮食的大鼠中，4周时测定的表观钙吸收、钙潴留以及小肠腔内可溶性钙含量显著（p < 0.05）高于喂食对照饮食的大鼠。各组之间股骨的湿重、长度和钙含量无显著差异。这些结果表明，在ISP饮食中，增强钙吸收的CPP最小有效剂量为0.7 g/kg或CPP/Ca重量比为0.2，并且补充CPP至少在膳食钙水平较低的情况下具有显著增加钙吸收的作用。
