Tsuchita H, Sekiguchi I, Kuwata T, Igarashi C, Ezawa I
Central Research Institute, Meiji Milk Products Co., Ltd., Higashimurayamashi, Japan.
Z Ernahrungswiss. 1993 Jun;32(2):121-30. doi: 10.1007/BF01614755.
The effect of casein phosphopeptides (CPPs) on Ca utilization in ovariectomized (OVX) rats was studied. A mixture of CPPs corresponding to the amino acid sequences 1-25 and 1-28 in the beta-casein was isolated from the tryptic digest of beta-casein (beta CPP). After being fed a low Ca diet for 30 days, OVX rats were fed experimental diets of which the Ca level was 0.1%, 0.3% or 0.5% with or without 0.15% beta CPP for 28 days. During days 1-3 of the Ca refeeding period, rats fed beta CPP with 0.5% Ca showed a higher Ca absorption than control rats not supplemented with beta CPP. During days 7-9 and 26-28, there were no significant differences in Ca and P balances between the beta CPP group and the control group for each dietary Ca level. Femoral Ca and P contents from rats fed beta CPP tended to be higher than those from control rats. These results suggest that beta CPP supplementation could have an effect on Ca absorption at a certain degree of Ca deficiency.
研究了酪蛋白磷酸肽（CPPs）对去卵巢（OVX）大鼠钙利用的影响。从β-酪蛋白的胰蛋白酶消化物中分离出对应于β-酪蛋白中氨基酸序列1-25和1-28的CPP混合物（β-CPP）。给OVX大鼠喂食低钙饮食30天后，再给它们喂食钙水平为0.1%、0.3%或0.5%且添加或不添加0.15%β-CPP的实验饮食28天。在补钙期的第1-3天，喂食含0.5%钙的β-CPP的大鼠比未补充β-CPP的对照大鼠表现出更高的钙吸收率。在第7-9天和第26-28天，对于每种饮食钙水平，β-CPP组和对照组之间的钙和磷平衡没有显著差异。喂食β-CPP的大鼠股骨中的钙和磷含量往往高于对照大鼠。这些结果表明，在一定程度的钙缺乏情况下，补充β-CPP可能对钙吸收有影响。
