Löffelholz K
Department of Pharmacology, University of Mainz, Germany.
J Physiol Paris. 1998 Jun-Aug;92(3-4):235-9. doi: 10.1016/s0928-4257(98)80025-9.
Choline is product and precursor to both acetylcholine and membrane phospholipids, and, in the brain, is ultimately provided by the circulation. The brain is protected from excess choline and choline deprivation by a refined system of homeostatic mechanisms that maintain a level of extracellular choline that, for its role as precursor, meets saturation criteria under normal conditions. The kinetic and activity profiles of choline are typical for a biosynthetic precursor.
胆碱既是乙酰胆碱和膜磷脂的产物，也是它们的前体，在大脑中，胆碱最终由循环系统提供。大脑通过一套精细的稳态机制系统来保护自身免受过量胆碱和胆碱缺乏的影响，该系统能维持细胞外胆碱的水平，使其作为前体，在正常情况下满足饱和标准。胆碱的动力学和活性特征是生物合成前体的典型特征。
