血清素抑制大鼠初级视觉皮层中长时程增强的诱导。
Serotonin inhibits the induction of long-term potentiation in rat primary visual cortex.
作者信息
Edagawa Y, Saito H, Abe K
机构信息
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1998 Aug;22(6):983-97. doi: 10.1016/s0278-5846(98)00055-4.
PMID:9789882
Abstract
- The effect of serotonin (5-hydroxytryptamine; 5-HT) on the induction of long-term potentiation (LTP) in rat visual cortex was investigated by using slice preparations in vitro. 2. Bath application of 5-HT (0.1-10 microM) did not affect the baseline synaptic potentials evoked by single-pulse test stimulation, but inhibited the induction of LTP in a concentration-dependent manner. 3. The effect of 5-HT was blocked by the 5-HT1 receptor antagonist pindolol or the 5-HT2,7 receptor antagonist ritanserin, but not by the 5-HT3,4 receptor antagonist MDL72222. 4. These results suggest that 5-HT plays a role in suppressing the induction of LTP in the rat visual cortex.
摘要
- 利用体外脑片制备技术，研究了血清素（5-羟色胺；5-HT）对大鼠视觉皮层长时程增强（LTP）诱导的影响。2. 浴槽中应用5-HT（0.1 - 10 microM）不影响单脉冲测试刺激诱发的基线突触电位，但以浓度依赖的方式抑制LTP的诱导。3. 5-HT1受体拮抗剂吲哚洛尔或5-HT2,7受体拮抗剂利坦色林可阻断5-HT的作用，但5-HT3,4受体拮抗剂MDL72222则不能。4. 这些结果表明，5-HT在抑制大鼠视觉皮层LTP的诱导中起作用。
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