May-Hegglin异常中的巨核细胞多倍体化。

Megakaryocyte polyploidization in May-Hegglin anomaly.

作者信息

Mayer M, Sperling H, Schaefer J, Queisser W

出版信息

Acta Haematol. 1978;60(1):45-52. doi: 10.1159/000207694.

DOI:10.1159/000207694

Abstract

Polyploidization of megakaryocytes was studied in bone marrow aspirates from 3 patients with May-Hegglin anomaly by combined application of cytophotometric determination of the DNA content and autoradiography with 3H-TdR labeling in vitro. A marked elevation of the influx of progenitor cells into the megakaryocytic cell system as well as a decreased maturation capacity from type II to type III megakaryocytes was observed possibly contributing to the pathological platelet sequestration. The polyploidization activity as assessed by 3H-TdR labeling and nuclear DNA content was normal.

摘要

通过联合应用细胞光度法测定DNA含量以及体外3H-TdR标记的放射自显影技术，对3例May-Hegglin异常患者的骨髓穿刺液中的巨核细胞多倍体化进行了研究。观察到祖细胞向巨核细胞系统的流入显著增加，以及从II型到III型巨核细胞的成熟能力下降，这可能导致了病理性血小板滞留。通过3H-TdR标记和核DNA含量评估的多倍体化活性正常。