Levin R J, Hamill N J, Grenko R T, Huang M Y, Fedok F G
Section of Otolaryngology/Head & Neck Surgery, Penn State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
Head Neck. 1998 Dec;20(8):753-7. doi: 10.1002/(sici)1097-0347(199812)20:8<753::aid-hed15>3.0.co;2-v.
Catecholamine secretion by head and neck paragangliomas is uncommon. Dopamine secretion by these tumors has not routinely been assessed. This case report describes a dopamine-secreting glomus vagale and evaluates seven other paragangliomas immunohistochemically for their ability to synthesize dopamine.
Light microscopic and immunohistochemical studies were performed on eight tumors, and biochemical testing for serum/urine catecholamines was performed on two patients.
One patient (case report) had elevated serum dopamine which corrected following surgery. Five tumors stained strongly positive for the presence of tyrosine hydroxylase, the critical enzyme in the biosynthesis of dopamine.
This case report describes the ability of a glomus vagale to secrete dopamine. Other paragangliomas express the enzymatic machinery necessary to begin catecholamine synthesis. Now that dopamine is routinely screened during catecholamine determination, other cases may be identified.
头颈部副神经节瘤分泌儿茶酚胺的情况并不常见。这些肿瘤分泌多巴胺的情况尚未常规评估。本病例报告描述了一例分泌多巴胺的迷走神经球瘤，并对其他七个副神经节瘤进行免疫组化评估，以检测它们合成多巴胺的能力。
对八个肿瘤进行了光镜和免疫组化研究，并对两名患者进行了血清/尿儿茶酚胺的生化检测。
一名患者（病例报告）血清多巴胺升高，术后恢复正常。五个肿瘤酪氨酸羟化酶染色呈强阳性，酪氨酸羟化酶是多巴胺生物合成中的关键酶。
本病例报告描述了迷走神经球瘤分泌多巴胺的能力。其他副神经节瘤表达启动儿茶酚胺合成所需的酶机制。既然在儿茶酚胺测定过程中常规筛查多巴胺，那么可能会发现其他病例。
