Huber A, Meyer M
Klin Monbl Augenheilkd. 1976 Jan;168(1):69-77.
An accurate differential diagnosis of ptosis results if one refers the functional disorders of the levator to the different levels of the motor unit: Muscle, synapsis, peripheral neuron and nucleus. Therefore ptosis can be classified into myogenic, synaptogenic and neurogenic forms. This classification is also based on electromyographic findings from the levator muscle. Myogenic forms of the ptosis are: Senile ptosis, chronic progressive ocular muscle dystrophy, acute exophthalmic myositis and affections of the levator together with general systemic myopathies. Synaptogenic forms of ptosis are: Botulism and myasthenia gravis. Neurogenic forms of ptosis are: Cortical ptosis, ptosis from lesions of the oculomotor nucleus (congenital ptosis, Moebius-syndrome), peripheral oculomotor palsy, ptosis in aberrant third nerve regeneration, sympathetic ptosis (Horner-syndrome), ptosis in cases of paradoxic innervation such as the Duane retraction-syndrome and the Marcus-Gunn-Jaw-Winking-syndrome (ptosis linked with jaw movement). According to the classification in myogenic, synaptogenic and peripheral-neurogenic forms of ptosis, the therapeutic possibilities (medical, surgical etc.) are discussed.
如果将提上睑肌的功能障碍归因于运动单位的不同层面,即肌肉、突触、周围神经元和神经核,就可以对睑下垂做出准确的鉴别诊断。因此,睑下垂可分为肌源性、突触源性和神经源性三种类型。这种分类也是基于提上睑肌的肌电图检查结果。睑下垂的肌源性类型包括:老年性睑下垂、慢性进行性眼肌营养不良、急性突眼性肌炎以及提上睑肌病变合并全身性肌病。睑下垂的突触源性类型包括:肉毒中毒和重症肌无力。睑下垂的神经源性类型包括:皮质性睑下垂、动眼神经核病变导致的睑下垂(先天性睑下垂、莫比乌斯综合征)、周围性动眼神经麻痹、第三神经异常再生导致的睑下垂、交感神经性睑下垂(霍纳综合征)、反常神经支配情况下的睑下垂,如杜安眼球后退综合征和马库斯 - 冈恩下颌瞬目综合征(与下颌运动相关的睑下垂)。根据睑下垂的肌源性、突触源性和周围神经源性类型分类,讨论了相应的治疗可能性(药物治疗、手术治疗等)。