Abdulkarim A S, Zein N N, Germer J J, Kolbert C P, Kabbani L, Krajnik K L, Hola A, Agha M N, Tourogman M, Persing D H
Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Am J Trop Med Hyg. 1998 Oct;59(4):571-6. doi: 10.4269/ajtmh.1998.59.571.
High prevalence of hepatitis C (HCV) and hepatitis G (HGV) viruses has been reported among hemodialysis patients with substantial heterogeneity of HCV genotypes throughout the world. We studied HCV prevalence, clinical significance, genotype distribution, and HGV coinfection in hemodialysis patients from Syria. Ninety (75%) of 120 screened patients were HCV antibody positive. Forty-nine (87.5%) of 56 HCV antibody-positive patients had HCV RNA detected by the polymerase chain reaction. The HCV genotyping was possible in 37 of 49 patients (76%). The HCV genotype distribution was genotype 1a, seven (19%); genotype 1b, 10 (27%); genotype 4a, 11 (30%); unmatched sequences, nine (24%). Phylogenetic analysis of unmatched sequences indicated that they represent two distinct and novel subtypes of HCV genotype 4. Hepatitis G virus RNA was detected in 29 (59%) of the HCV RNA-positive patients. No differences were identified between patients infected with HCV alone and those coinfected with HGV. These data demonstrate that HCV infection is common in this population with a genotype distribution predominantly made up of types 1 and 4. Coinfection with HGV had no effect on the outcome of HCV infection.
据报道，全世界血液透析患者中丙型肝炎病毒（HCV）和庚型肝炎病毒（HGV）感染率很高，且HCV基因型存在很大异质性。我们研究了叙利亚血液透析患者中的HCV感染率、临床意义、基因型分布及HGV合并感染情况。120例接受筛查的患者中，90例（75%）HCV抗体呈阳性。56例HCV抗体阳性患者中，49例（87.5%）通过聚合酶链反应检测到HCV RNA。49例患者中有37例（76%）能够进行HCV基因分型。HCV基因型分布为：1a型7例（19%）；1b型10例（27%）；4a型11例（30%）；不匹配序列9例（24%）。对不匹配序列的系统发育分析表明，它们代表HCV基因型4的两个不同的新型亚型。在HCV RNA阳性患者中，29例（59%）检测到HGV RNA。单独感染HCV的患者与合并感染HGV的患者之间未发现差异。这些数据表明，该人群中HCV感染很常见，基因型分布主要由1型和4型组成。HGV合并感染对HCV感染的结果没有影响。
