Weizel A
Klin Wochenschr. 1976 Aug 1;54(15):739-42. doi: 10.1007/BF01470466.
In vivo incorporation studies with 4-14C-cholesterol were performed in five patients with cirrhosis of the liver. All patients showed low concentrations of total cholesterol, esterified cholesterol, and a low activity of the lecithin: cholesterol acyltransferase activity (LCAT). The pattern of incorporation corresponded to the results known from hypercholesterolemic, normocholesterolemic and hypertriglyceridemic patients. Low cholesterol ester concentrations and low LCAT activity do not modify the pattern of incorporation into the lipoprotein ester fractions.
对五名肝硬化患者进行了4-¹⁴C-胆固醇的体内掺入研究。所有患者的总胆固醇、酯化胆固醇浓度均较低,卵磷脂:胆固醇酰基转移酶活性(LCAT)也较低。掺入模式与高胆固醇血症、正常胆固醇血症和高甘油三酯血症患者的已知结果一致。低胆固醇酯浓度和低LCAT活性不会改变脂蛋白酯组分中的掺入模式。