感染新型TT DNA病毒的肝细胞癌缺乏病毒整合。
Hepatocellular carcinomas infected with the novel TT DNA virus lack viral integration.
作者信息
Yamamoto T, Kajino K, Ogawa M, Gotoh I, Matsuoka S, Suzuki K, Moriyama M, Okubo H, Kudo M, Arakawa Y, Hino O
机构信息
Department of Experimental Pathology, Cancer Institute, Kami-Ikebukuro, Toshima-ku, Tokyo, 170-8455, Japan.
出版信息
Biochem Biophys Res Commun. 1998 Oct 9;251(1):339-43. doi: 10.1006/bbrc.1998.9420.
A novel DNA virus designated TT virus (TTV) was cloned from a patient with posttransfusion hepatitis and is thought to be a new hepatitis virus. At present, hepatitis B virus (HBV) and hepatitis C virus (HCV) are known to induce hepatocellular carcinoma (HCC). But, actually, in Japan approximately 5 to 10% of HCCs are in HBV-negative and HCV-negative (NBNC) patients. In order to study the possible role of TTV in hepatocarcinogenesis, we investigated the frequency of the TTV genome in liver tissue of 20 HCC patients. As a result, 3 of 8 NBNC HCC patients and 5 of 12 HBV- or HCV-associated HCC patients were TTV positive, and TTV was shown not to be specific for NBNC HCC. For all TTV-positive patients, we also confirmed that the TTV genome was not integrated into host hepatocyte DNA.
一种名为TT病毒（TTV）的新型DNA病毒是从一名输血后肝炎患者体内克隆出来的，被认为是一种新型肝炎病毒。目前已知乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）可诱发肝细胞癌（HCC）。但实际上，在日本，约5%至10%的肝细胞癌患者为HBV阴性和HCV阴性（NBNC）患者。为了研究TTV在肝癌发生过程中可能发挥的作用，我们调查了20例肝细胞癌患者肝组织中TTV基因组的出现频率。结果显示，8例NBNC肝细胞癌患者中有3例、12例HBV或HCV相关性肝细胞癌患者中有5例TTV呈阳性，且TTV并非NBNC肝细胞癌所特有。对于所有TTV阳性患者，我们还证实TTV基因组未整合到宿主肝细胞DNA中。
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