Yamamoto T, Kajino K, Ogawa M, Gotoh I, Matsuoka S, Suzuki K, Moriyama M, Okubo H, Kudo M, Arakawa Y, Hino O
Department of Experimental Pathology, Cancer Institute, Kami-Ikebukuro, Toshima-ku, Tokyo, 170-8455, Japan.
Biochem Biophys Res Commun. 1998 Oct 9;251(1):339-43. doi: 10.1006/bbrc.1998.9420.
A novel DNA virus designated TT virus (TTV) was cloned from a patient with posttransfusion hepatitis and is thought to be a new hepatitis virus. At present, hepatitis B virus (HBV) and hepatitis C virus (HCV) are known to induce hepatocellular carcinoma (HCC). But, actually, in Japan approximately 5 to 10% of HCCs are in HBV-negative and HCV-negative (NBNC) patients. In order to study the possible role of TTV in hepatocarcinogenesis, we investigated the frequency of the TTV genome in liver tissue of 20 HCC patients. As a result, 3 of 8 NBNC HCC patients and 5 of 12 HBV- or HCV-associated HCC patients were TTV positive, and TTV was shown not to be specific for NBNC HCC. For all TTV-positive patients, we also confirmed that the TTV genome was not integrated into host hepatocyte DNA.
一种名为TT病毒（TTV）的新型DNA病毒是从一名输血后肝炎患者体内克隆出来的，被认为是一种新型肝炎病毒。目前已知乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）可诱发肝细胞癌（HCC）。但实际上，在日本，约5%至10%的肝细胞癌患者为HBV阴性和HCV阴性（NBNC）患者。为了研究TTV在肝癌发生过程中可能发挥的作用，我们调查了20例肝细胞癌患者肝组织中TTV基因组的出现频率。结果显示，8例NBNC肝细胞癌患者中有3例、12例HBV或HCV相关性肝细胞癌患者中有5例TTV呈阳性，且TTV并非NBNC肝细胞癌所特有。对于所有TTV阳性患者，我们还证实TTV基因组未整合到宿主肝细胞DNA中。
