Romanov V S
Kosm Biol Aviakosm Med. 1976 Jul-Aug;10(4):50-4.
It was morphometrically shown that during 120-day hypokinesia chromatin redistribution was similar in nuclei of myocardial cells of the ventricles of the rat heart. Quantitative rearrangements in the mitochondrial apparatus of cells were of different pattern. On the 14th hypokinetic day the number of mitochondria increased and their size decreased; on the 30th day their size increased and their number decreased; on the 45 and 60th day the number and size of mitochondria returned to the normal; on the 120th hypokinetic day the number and size of mitochondria were higher than the control. Throughout the 120-day experimental the ratio of the total area of mitochondria to the total area of myofibers varied periodically and by the end of the experimental the mitochondrial area increased. Thus, it is obvious that by the 120th hypokinetic day myocardial changes increased indicating a new level of cardiac activity during prolonged hypokinesia. Quantitative changes in the organelles of the myocardium of the left ventricle were more significant than those of the right ventricle during the exposure.
形态测量结果表明，在120天的运动减退期间，大鼠心脏心室心肌细胞核内的染色质重新分布情况相似。细胞线粒体装置的定量重排呈现出不同的模式。在运动减退的第14天，线粒体数量增加而其大小减小；在第30天，其大小增加而数量减少；在第45天和60天，线粒体的数量和大小恢复正常；在运动减退的第120天，线粒体的数量和大小高于对照组。在整个120天的实验过程中，线粒体总面积与肌纤维总面积的比值呈周期性变化，到实验结束时线粒体面积增加。因此，很明显，到运动减退的第120天，心肌变化加剧，表明在长期运动减退期间心脏活动达到了一个新水平。在暴露期间，左心室心肌细胞器的定量变化比右心室更显著。
