Chong C Y, Tan A M, Lou J
Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore.
Ann Acad Med Singap. 1998 Jul;27(4):491-5.
We did a retrospective study of all acute lymphoblastic leukaemia (ALL) patients on United Kingdom ALL protocol who were admitted for febrile neutropenia. The aim of the study was to document the types of infections and aetiological agents associated with febrile neutropenia and to document the factors affecting mortality. Over the 8 1/2-year period from 1986 to June 1995, there were 77 episodes in 32 children with a mean of 2.4 episodes. Morbidity due to infection was 61%; unknown causes of fever contributed 39%. Of the microbiologically documented infections, majority were Gram-negative bacteraemia. There were 7 deaths (22%) during the study period, 3 (9%) of which were due to overwhelming sepsis, with 4 contributed by the relapse status of the leukaemia. Mortality was increased by prolonged neutropenia, relapse of the leukaemia and invasive fungal infection.
我们对所有按照英国急性淋巴细胞白血病（ALL）治疗方案治疗且因发热性中性粒细胞减少症入院的患者进行了一项回顾性研究。该研究的目的是记录与发热性中性粒细胞减少症相关的感染类型和病原体，并记录影响死亡率的因素。在1986年至1995年6月的8年半时间里，32名儿童共出现77次发作，平均每人2.4次发作。感染导致的发病率为61%；不明原因发热占39%。在微生物学确诊的感染中，大多数为革兰氏阴性菌血症。研究期间有7例死亡（22%），其中3例（9%）死于严重败血症，4例由白血病复发导致。中性粒细胞减少持续时间延长、白血病复发和侵袭性真菌感染会增加死亡率。
