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[直肠癌治疗的最新方法]

[Up-to-date approach to the treatment of rectal cancer].

作者信息

Pokrovskiĭ G A, Odariuk T S, Tsar'kov P V, Eropkin P V, Shelygin Iu A

出版信息

Khirurgiia (Mosk). 1998(9):54-61.

PMID:9791992
Abstract

During the last 15 years 2404 radical operations of various types were carried out for cancer of the rectum. The rate of postoperative complications made up 28.3% and mortality--2.9%. The tendency to increase of locally spread forms of cancer up to 96.2% with metastases to regional lymph nodes up to--52.3% was detected. The use of adequate chemotherapy, updated suturing devices and new variants of radical operations, combined and extended ones in particular havw much contributed to carrying out radical interventions with complete restoration of bowel continuity in 70% of patients. 5 year survival rate of patients after sphincter saving plastics and restorative procedures made up 60.2-65.3%, after extirpations with colostomy--54.2%. Promising results of improvement the indices of 5 year survival were obtained when preoperative irradiation in regime of multifractioning SOD 45-55 Gy was used together with administration of 5-fluorouracil (5-7.5 g).

摘要

在过去15年里,针对直肠癌进行了2404例各类根治性手术。术后并发症发生率为28.3%,死亡率为2.9%。发现局部扩散型癌症的比例上升至96.2%,区域淋巴结转移率高达52.3%。使用适当的化疗、更新的缝合器械以及根治性手术的新术式,特别是联合和扩大手术,对70%的患者进行根治性干预并完全恢复肠道连续性起到了很大作用。保留括约肌整形和修复手术后患者的5年生存率为60.2% - 65.3%,结肠造口切除术后为54.2%。当采用多分割SOD 45 - 55 Gy方案的术前放疗并同时给予5 - 氟尿嘧啶(5 - 7.5克)时,在改善5年生存指标方面取得了有前景的结果。

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