Macieira-Coelho A
INSERM and University of Paris VI, Versailles, France.
Mech Ageing Dev. 1998 Aug 14;104(2):207-11. doi: 10.1016/s0047-6374(98)00087-6.
In the current literature cells that have finished their proliferative life span in vitro and have reached a terminal post-mitotic state are called senescent cells. This definition originated from the belief that the irreversible non-dividing state has a relationship with aging of the organism. Attempts have been made to find markers of the so-called senescent cell in order to detect their presence in vivo in donors of different ages. One marker which was supposed to demonstrate an increase of post-mitotic cells with aging is a marker of a long resting phase whether reversible or irreversible. Other markers suggest that the postmitotic cell does not increase with aging of the organism, that it is irrelevant for aging, that it is found in an increased number in pathology, and that the term senescent cell is a misnomer that should be used only in an operational manner.
在当前文献中，那些在体外已完成增殖寿命并达到终末有丝分裂后状态的细胞被称为衰老细胞。这一定义源于这样一种观点，即不可逆的非分裂状态与生物体的衰老有关。人们试图寻找所谓衰老细胞的标志物，以便在不同年龄供体的体内检测到它们的存在。一个被认为能证明有丝分裂后细胞随衰老而增加的标志物是处于长静止期的标志物，无论该静止期是可逆的还是不可逆的。其他标志物表明，有丝分裂后细胞并不会随着生物体的衰老而增加，它与衰老无关，在病理状态下数量会增加，并且“衰老细胞”这个术语是用词不当，应该仅在操作层面使用。
