Abbadie C, Basbaum A I
Department of Anatomy, University of California San Francisco, 94143-0452, USA.
Neurosci Lett. 1998 Sep 11;253(3):143-6. doi: 10.1016/s0304-3940(98)00642-9.
Transection of the sciatic nerve leads to sprouting of sympathetic efferent, noradrenergic axons and terminals around large cell bodies in the dorsal root ganglion. Here we examined whether injury to unmyelinated afferents contributes to the sprouting. Neonatal treatment with the C-fiber neurotoxin capsaicin increased sprouting after nerve injury. We conclude that injury to large, rather than small diameter fibers, triggers the sprouting of sympathetic efferents after nerve injury.
坐骨神经横断会导致背根神经节中大型细胞体周围的交感传出、去甲肾上腺素能轴突和终末发生芽生。在此，我们研究了无髓传入纤维损伤是否促成了这种芽生。用C纤维神经毒素辣椒素对新生动物进行处理会增加神经损伤后的芽生。我们得出结论，是大直径而非小直径纤维的损伤触发了神经损伤后交感传出纤维的芽生。
