Mustelin T, Brockdorff J, Gjörloff-Wingren A, Tailor P, Han S, Wang X, Saxena M
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
Front Biosci. 1998 Nov 1;3:D1060-96. doi: 10.2741/a346.
The molecular mechanisms of signal transduction have been at the focus of intense scientific research world-wide. As a result, our understanding of protein tyrosine kinase-mediated signaling has advanced at an unprecedented pace during the past decade. In contrast, the study of protein tyrosine phosphatases is in its infancy, but is currently gathering momentum and is predicted to become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the art in our understanding of the structure, regulation and role of protein tyrosine phosphatases in lymphocyte activation.
信号转导的分子机制一直是全球范围内激烈科学研究的焦点。因此，在过去十年中，我们对蛋白酪氨酸激酶介导的信号传导的理解以前所未有的速度取得了进展。相比之下，蛋白酪氨酸磷酸酶的研究尚处于起步阶段，但目前正在加速发展，预计在未来几年内将成为该领域的一个“热门话题”。本综述总结了我们目前对蛋白酪氨酸磷酸酶在淋巴细胞激活中的结构、调节和作用的理解的最新进展。
