26,26,26,27,27,27-六氟-1,25-二羟基维生素D3对维生素D缺乏小鼠中维生素D反应性基因表达的影响。

Effect of 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3 on the expression of vitamin-D-responsive genes in vitamin-D-deficient mice.

作者信息

Yoshimura T, Itoh S, Tsujikawa K, Yamada E, Ishii T, Iemura O, Kameda Y, Mimura T, Kohama Y

机构信息

Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

出版信息

Pharmacology. 1998 Dec;57(6):286-94. doi: 10.1159/000028254.

DOI:10.1159/000028254

PMID:9792969

Abstract

26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3 (ST-630) is a newly developed agent to maintain the levels of calcium and phosphorus in blood. Herein, we investigated the effect of this compound on the expression of vitamin-D-responsive genes in vitamin-D-deficient mice. ST-630 was more effective than 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3] with respect to the induction of Cyp24 and calbindin-D9k mRNAs in the kidney and in the small intestine. Moreover, the increase in mRNA levels of vitamin-D-responsive genes induced by ST-630 lasted longer than that induced by 1,25(OH)2D3. These results indicate that ST-630 was more effective in inducing Cyp24 and calbindin-D9k gene expression than 1, 25(OH)2D3 when both compounds were injected into vitamin-D-deficient mice.

摘要

26,26,26,27,27,27-六氟-1,25-二羟基维生素D3（ST-630）是一种新研发的用于维持血液中钙和磷水平的药物。在此，我们研究了该化合物对维生素D缺乏小鼠中维生素D反应性基因表达的影响。在诱导肾脏和小肠中Cyp24和钙结合蛋白-D9k mRNA表达方面，ST-630比1,25-二羟基维生素D3 [1,25(OH)2D3]更有效。此外，ST-630诱导的维生素D反应性基因mRNA水平的增加持续时间比1,25(OH)2D3诱导的更长。这些结果表明，当将这两种化合物注射到维生素D缺乏的小鼠体内时，ST-630在诱导Cyp24和钙结合蛋白-D9k基因表达方面比1,25(OH)2D3更有效。