大鼠主动脉和颈动脉对α1-肾上腺素能受体刺激反应性的成熟及衰老相关差异

Maturation and aging-related differences in responsiveness of rat aorta and carotid arteries to alpha1-adrenoceptor stimulation.

作者信息

de Oliveira A M, Campos-Mello C, Leitão M C, Correa F M

机构信息

Laboratory of Pharmacology, School of Pharmaceutical Science, University of São Paulo, Ribeirão Preto, SP, Brazil.

出版信息

Pharmacology. 1998 Dec;57(6):305-13. doi: 10.1159/000028256.

DOI:10.1159/000028256

PMID:9792971

Abstract

Functional correlates of alpha1-adrenoceptors were studied in thoracic aorta and carotid arteries from Wistar rats, at maturation (3- and 8-week-old) and aging (17- and 29-week-old) phases, using phenylephrine (PHE) and KCl. PHE and KCl effects on rat aorta did not differ with age. A reduction in maximal contractions to PHE or KCl occurred in carotid arteries during maturation. Concentration-inhibition curves to the alkylating agent chloroethylclonidine or WB4101 suggested at all ages studied a predominance of alpha1B-adrenoceptors in aorta. However, alpha1A-adrenoceptors may account for some activity in aortas of 29-week-old rats. In carotid arteries alpha1D-adrenoceptors account for functional correlates at all ages studied. The results indicate that maturation or aging affects vascular responsiveness or predominant receptor subtype differently in aorta and carotid arteries with intact endothelium.

摘要

利用去氧肾上腺素（PHE）和氯化钾（KCl），研究了Wistar大鼠在成熟阶段（3周龄和8周龄）和衰老阶段（17周龄和29周龄）胸主动脉和颈动脉中α1肾上腺素能受体的功能相关性。PHE和KCl对大鼠主动脉的作用不随年龄而变化。在成熟过程中，颈动脉对PHE或KCl的最大收缩反应降低。对烷基化剂氯乙可乐定或WB4101的浓度抑制曲线表明，在所有研究年龄中，主动脉中α1B肾上腺素能受体占主导地位。然而，α1A肾上腺素能受体可能参与了29周龄大鼠主动脉的一些活性。在颈动脉中，α1D肾上腺素能受体在所有研究年龄中均与功能相关性有关。结果表明，成熟或衰老对完整内皮的主动脉和颈动脉的血管反应性或主要受体亚型的影响不同。