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Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family.

作者信息

de Groot R P, Coffer P J, Koenderman L

机构信息

Department of Pulmonary Diseases, University Hospital Utrecht, The Netherlands.

出版信息

Cell Signal. 1998 Oct;10(9):619-28. doi: 10.1016/s0898-6568(98)00023-0.

DOI:10.1016/s0898-6568(98)00023-0
PMID:9794243
Abstract

The receptors for the I1-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric complex of a cytokine-specific alpha chain and a common beta chain (betac). Binding of IL-3/IL-5/GM-CSF to their respective receptors rapidly induces activation of multiple intracellular signalling pathways, including the Ras-Raf-ERK, the JAK/STAT, the phosphatidylinositol 3-kinase PKB, and the JNK/SAPK and p38 signalling pathways. This review focuses on recent advancements in understanding how these different signalling pathways are activated by IL-3/IL-5/GM-CSF receptors, and how the individual pathways contribute to the pleiotropic effects of IL-3/IL-5/GM-CSF on their target cells, including proliferation, differentiation, survival, and effector functions.

摘要

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