激素替代疗法对QT间期的影响。
Effects of hormone replacement therapy on QT interval.
作者信息
Larsen J A, Tung R H, Sadananda R, Goldberger J J, Horvath G, Parker M A, Kadish A H
机构信息
Department of Internal Medicine, Northwestern University Medical School, Chicago, Illinois, USA.
出版信息
Am J Cardiol. 1998 Oct 15;82(8):993-5. doi: 10.1016/s0002-9149(98)00523-2.
We evaluated the electrocardiograms of 208 postmenopausal women (ages 40 to > or = 70 years) without heart disease, medications that could alter the QT interval, use of vaginal estrogens, unknown hormone replacement therapy, or electrocardiographic abnormalities both with (n = 76) and without (n = 132) hormone replacement therapy, and found no significant effects of hormone replacement therapy status on heart rate, QT interval, or the corrected QT interval. Thus, estrogen and/or progesterone effect does not explain the gender differences in myocardial repolarization.
我们评估了208名无心脏病、无可改变QT间期的药物使用、未使用阴道雌激素、激素替代疗法情况不明或无心电图异常的绝经后女性（年龄40至≥70岁）的心电图，其中接受激素替代疗法的有76人，未接受激素替代疗法的有132人，结果发现激素替代疗法状态对心率、QT间期或校正QT间期无显著影响。因此，雌激素和/或孕激素作用无法解释心肌复极化的性别差异。
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