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The controlled clinical trial turns 100 years: Fibiger's trial of serum treatment of diphtheria.

作者信息

Hróbjartsson A, Gøtzsche P C, Gluud C

机构信息

Nordic Cochrane Centre, H:S Rigshospitalet, Tagensvej 18 B, DK-2200 Copenhagen N, Denmark.

出版信息

BMJ. 1998 Oct 31;317(7167):1243-5. doi: 10.1136/bmj.317.7167.1243.

Abstract
摘要

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本文引用的文献

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[Causal evaluation of therapy].
Ugeskr Laeger. 1951 Nov 29;113(48):1625-30.
4
The historical development of clinical therapeutic trials.
J Chronic Dis. 1959 Sep;10:218-48. doi: 10.1016/0021-9681(59)90004-9.
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Early controlled trials .... but "quasirandom allocation " of treatment was reported in 1930.
BMJ. 1996 May 18;312(7041):1298. doi: 10.1136/bmj.312.7041.1298a.
7
Johannes Fibiger and his Nobel Prize for the hypothesis that a worm causes stomach cancer.
Ann Intern Med. 1992 May 1;116(9):765-9. doi: 10.7326/0003-4819-116-9-765.
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Johannes Fibiger. Gongylonema and vitamin A in carcinogenesis.
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