地衣代谢产物的体外抗分枝杆菌活性

Antimycobacterial activity of lichen metabolites in vitro.

作者信息

Ingólfsdóttir K, Chung G A, Skúlason V G, Gissurarson S R, Vilhelmsdóttir M

机构信息

Department of Pharmacy, University of Iceland, Hagi/Hofsvallagata, 107 Reykjavik, Iceland.

出版信息

Eur J Pharm Sci. 1998 Apr;6(2):141-4. doi: 10.1016/s0928-0987(97)00078-x.

DOI:10.1016/s0928-0987(97)00078-x

PMID:9795033

Abstract

Several compounds, whose structures represent the most common chemical classes of lichen metabolites, were screened for in vitro activity against Mycobacterium aurum, a non-pathogenic organism with a similar sensitivity profile to M. tuberculosis. Of the compounds tested, usnic acid from Cladonia arbuscula exhibited the highest activity with an MIC value of 32 microg/ml. Atranorin and lobaric acid, both isolated from Stereocaulon alpinum, salazinic acid from Parmelia saxatilis and protolichesterinic acid from Cetraria islandica all showed MIC values >/=125 microg/ml.

摘要

对几种化合物进行了筛选，这些化合物的结构代表了地衣代谢物中最常见的化学类别，以检测其对金色分枝杆菌的体外活性，金色分枝杆菌是一种非致病性生物体，其敏感性与结核分枝杆菌相似。在测试的化合物中，来自丛生石蕊的松萝酸表现出最高活性，最低抑菌浓度（MIC）值为32微克/毫升。从高山石蕊中分离出的阿特拉诺林和洛巴酸、从石耳中分离出的柳酸以及从冰岛衣中分离出的原地衣硬酸，其最低抑菌浓度值均≥125微克/毫升。